Dbx1^{tm1(cre/ERT2)Jcor}
Targeted Allele Detail

Summary

• Symbol: Dbx1^{tm1(cre/ERT2)Jcor}
• Name: developing brain homeobox 1; targeted mutation 1, Joshua Corbin
• MGI ID: MGI:3837011
• Synonyms: Dbx1^CreERT2
• Gene: Dbx1 Location: Chr7:49281247-49286583 bp, - strand Genetic Position: Chr7, 31.44 cM
• Alliance: Dbx1^{tm1(cre/ERT2)Jcor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146178
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Dbx1^{tm1(cre/ERT2)Jcor} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dbx1 (MGI:94867)

• Mutation details: An IRES-cre/ERT2 (Esr1), and neo cassette were inserted into the downstream untranslated region. Germ line flp mediated recombination was used to remove the neo cassette. (J:146178)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dbx1 (mouse) Summary of all recombinase alleles driven by Dbx1. Comparative matrix view of recombinase activities Alliance mouse Dbx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbx1 Mutation: 25 strains or lines available

References

• Original: J:146178 Hirata T, et al., Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Nat Neurosci. 2009 Feb;12(2):141-9
• All: 18 reference(s)