Lmnatm4Lgf
Targeted Allele Detail
|
Symbol: |
Lmnatm4Lgf |
Name: |
lamin A; targeted mutation 4, Loren G Fong |
MGI ID: |
MGI:3837135 |
Synonyms: |
LmnaggHG |
Gene: |
Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
|
Alliance: |
Lmnatm4Lgf page
|
|
Rib fractures in Lmnatm4Lgf/Lmna+ and Lmnatm1Lgf/Lmna+ mice
Show the 2 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:146099
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion, Single point mutation
|
|
|
Mutation details: Introns 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A point mutation in exon 12 resulted in the amino acid substitution of leucine for methionine within the CaaX motif. This substitution triggers protein geranylgeranylation. A floxed neo cassette downstream of exon 12 was used for selection.
(J:146099)
|
|
Generation of the Lmnatm4Lgf allele |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Lmna Mutation: |
84 strains or lines available
|
|
Original: |
J:146099 Davies BS, et al., Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan;50(1):126-34 |
All: |
1 reference(s) |
|