Mapk14^tm1Jda
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Jda
• Name: mitogen-activated protein kinase 14; targeted mutation 1, Jonathan D Ashwell
• MGI ID: MGI:3837139
• Synonyms: p38alpha^Y323F
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions in exon 11 resulted in the amino acid substitution of phenylalanine for tyrosine at position 323 (Y323F). A floxed neo cassette was inserted upstream of exon 11. (J:146088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:146088 Jirmanova L, et al., Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production. Blood. 2009 Mar 5;113(10):2229-37
• All: 8 reference(s)