Drinkcala3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Drinkcala3^C57BL/6J
• Name: drink calcium lactate 3; C57BL/6J
• MGI ID: MGI:3837191
• QTL: Drinkcala3 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased calcium lactate intake and preference compared to PWK/PhJ. (J:144262)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144262

Linkage analysis was performed on (C57BL/6J x PWK/PhJ)F2 animals to identify genetic loci associated with preference and intake of calcium and other salt compounds. Animals were subjected to a two-bottle choice test between water and one other solution (CaCl2, CaLa, MgCl2, KCl, NH4Cl, NaCl, citric acid, QHCl, or saccharin) for a period of 96 hours. PWK/PhJ is a high consumer of calcium chloride (CaCl2) and calcium lactate (CaLa) whereas C57BL/6J is a relatively low consumer. PWK/PhJ also consumes more MgCl2 compared to C57BL/6J. However, when consumption of KCl, NaCl and saccharin were analyzed, C57BL/6J animals consumed more of these solutions compared to PWK/PhJ animals. Linkage analysis was performed using 116 polymorphic markers at a resolution of 10cM - 30cM. Thirty QTLs reaching statistical significance were identified. Authors assigned separate QTL nomenclature for each of the salt compound QTL even if they mapped to the same linkage marker.

On mouse Chromosome 2, significant linkage to CaLa intake and preference mapped to 86 cM (153 Mb) near D2Mit285 (LOD=3.7 and 3.5, respectively). This locus is named Drinkcala3 (drink calcium lactate 3). Drinkcala3 explains 4.4% of the CaLa intake variance and 4.6% of the variance for CaLa preference. C57BL/6J-derived alleles at Drinkcala3 confer increased CaLa intake and preference with a recessive mode of inheritance. Linkage to MgCl2 intake also mapped to 86 cM with LOD=3.7 and is named Drinkmgcl23 (drink magnesium chloride 2 3). C57BL/6J-derived alleles at Drinkmgcl23 confer increased MgCl2 consumption with a recessive mode of inheritance. This locus explains 3.4% of the variance in MgCl2 intake.

References

• Original: J:144262 Tordoff MG, et al., Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice. Genes Brain Behav. 2008 Aug;7(6):618-28
• All: 1 reference(s)