Drinkkcl4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Drinkkcl4^C57BL/6J
• Name: drink potassium chloride 4; C57BL/6J
• MGI ID: MGI:3837195
• QTL: Drinkkcl4 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased potassium chloride intake compared to PWK/PhJ. (J:144262)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144262

Linkage analysis was performed on (C57BL/6J x PWK/PhJ)F2 animals to identify genetic loci associated with preference and intake of calcium and other salt compounds. Animals were subjected to a two-bottle choice test between water and one other solution (CaCl2, CaLa, MgCl2, KCl, NH4Cl, NaCl, citric acid, QHCl, or saccharin) for a period of 96 hours. PWK/PhJ is a high consumer of calcium chloride (CaCl2) and calcium lactate (CaLa) whereas C57BL/6J is a relatively low consumer. PWK/PhJ also consumes more MgCl2 compared to C57BL/6J. However, when consumption of KCl, NaCl and saccharin were analyzed, C57BL/6J animals consumed more of these solutions compared to PWK/PhJ animals. Linkage analysis was performed using 116 polymorphic markers at a resolution of 10cM - 30cM. Thirty QTLs reaching statistical significance were identified. Authors assigned separate QTL nomenclature for each of the salt compound QTL even if they mapped to the same linkage marker.

On mouse Chromosome 3, significant linkage to KCl intake mapped to 13.8 cM (31 Mb) near D3Mit178 (LOD=5.9). This locus explains 5.6% of the phenotypic variance and is named Drinkkcl4 (drink potassium chloride 4). C57BL/6J-derived alleles at Drinkkcl4 confer increased KCl intake.

References

• Original: J:144262 Tordoff MG, et al., Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice. Genes Brain Behav. 2008 Aug;7(6):618-28
• All: 1 reference(s)