Dhx58^tm1Gnb
Targeted Allele Detail

Summary

• Symbol: Dhx58^tm1Gnb
• Name: DExH-box helicase 58; targeted mutation 1, Glen N Barber
• MGI ID: MGI:3837303
• Synonyms: Lgp2^-
• Gene: Dhx58 Location: Chr11:100585710-100595097 bp, - strand Genetic Position: Chr11, 63.52 cM
• Alliance: Dhx58^tm1Gnb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146113
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 6 were replaced with a floxed neo cassette. The absence of protein expression following treatment with IFN-beta was confirmed by western blot analysis on mouse embryo fibroblasts. (J:146113)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhx58 Mutation: 37 strains or lines available

References

• Original: J:146113 Venkataraman T, et al., Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol. 2007 May 15;178(10):6444-55
• All: 2 reference(s)