Adrb2^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Adrb2^tm1Kry
• Name: adrenergic receptor, beta 2; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:3837346
• Synonyms: Adrb2^flox, Adrbeta2-flox
• Gene: Adrb2 Location: Chr18:62310887-62313030 bp, - strand Genetic Position: Chr18, 35.1 cM
• Alliance: Adrb2^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and a floxed neo cassette was inserted downstream of exon 1. (J:145998)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adrb2 Mutation: 34 strains or lines available

References

• Original: J:145998 Hinoi E, et al., The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol. 2008 Dec 29;183(7):1235-42
• All: 24 reference(s)