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Gpr68tm1Aha
Targeted Allele Detail
Summary
Symbol: Gpr68tm1Aha
Name: G protein-coupled receptor 68; targeted mutation 1, Akihiro Harada
MGI ID: MGI:3837434
Synonyms: OGR1geo
Gene: Gpr68  Location: Chr12:100842941-100874457 bp, - strand  Genetic Position: Chr12, 51.1 cM
Alliance: Gpr68tm1Aha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146233
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing a bcl2 splice acceptor (SA) and a FRT-flanked beta-geo gene was inserted into the PvuII site upstream of exon 2. A loxP site was included upstream of the cassette and another loxP site was inserted into the BglII site in intron 3. Gene transcription is interrupted by the strong splice acceptor and terminated by a polyA sequence in the beta-geo gene. (J:146233, J:189192)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpr68 Mutation:  25 strains or lines available
References
Original:  J:146233 Mogi C, et al., Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol. 2009 Mar 1;182(5):3243-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory