Mapk13^tm2.1Lex
Targeted Allele Detail

Summary

• Symbol: Mapk13^tm2.1Lex
• Name: mitogen-activated protein kinase 13; targeted mutation 2.1, Lexicon Genetics
• MGI ID: MGI:3837446
• Synonyms: p38delta^delta
• Gene: Mapk13 Location: Chr17:28988260-28997678 bp, + strand Genetic Position: Chr17, 15.0 cM, cytoband A3-B
• Alliance: Mapk13^tm2.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119724
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 1. The absence of protein expression was confirmed by western blot analysis on pancreas and skeletal muscle extracts. (J:146185)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk13 Mutation: 26 strains or lines available

References

• Original: J:119724 Perdiguero E, et al., Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J. 2007 Mar 7;26(5):1245-56
• All: 6 reference(s)