Tg(Tek-icre/ERT2)1Soff
Transgene Detail

Summary

• Symbol: Tg(Tek-icre/ERT2)1Soff
• Name: transgene insertion 1, Stefan Offermanns
• MGI ID: MGI:3837451
• Synonyms: tie2-CreER^T2
• Transgene: Tg(Tek-icre/ERT2)1Soff Location: unknown
• Alliance: Tg(Tek-icre/ERT2)1Soff page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tek-icre/ERT2)1Soff expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: A tamoxifen-inducible icre recombinase gene and FRT-flanked beta-lactamase gene were inserted into the ATG start site of the murine Tek gene located on a BAC. After Flpe-mediated excision of the beta-lactamase gene, the targeted BAC was injected into FVB/N oocytes. Cre expression was detected in endothelial cells of numerous organs after treatment with tamoxifen. (J:146132)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:146132 Korhonen H, et al., Anaphylactic shock depends on endothelial Gq/G11. J Exp Med. 2009 Feb 16;206(2):411-20
• All: 22 reference(s)