Pink1^tm1Zhzh
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Zhzh
• Name: PTEN induced putative kinase 1; targeted mutation 1, Zhuohua Zhang
• MGI ID: MGI:3837552
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Zhzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146282
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 7 were replaced with an frt flanked neo cassette. The absence of transcript expression was confirmed by RT-PCR and in situ hybridization. (J:146282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:146282 Xiong H, et al., Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest. 2009 Mar;119(3):650-60
• All: 13 reference(s)