Gper1^tm1.1Lmlf
Targeted Allele Detail

Summary

• Symbol: Gper1^tm1.1Lmlf
• Name: G protein-coupled estrogen receptor 1; targeted mutation 1.1, L M Leeb-Lundberg
• MGI ID: MGI:3837567
• Synonyms: GPR30^-
• Gene: Gper1 Location: Chr5:139408906-139413555 bp, + strand Genetic Position: Chr5, 78.58 cM, cytoband G1
• Alliance: Gper1^tm1.1Lmlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146345
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with a floxed open reading frame and neo cassette. Transient cAMP reponse element-recombinase expression was used to remove the open reading frame in ES cells. The absence of transcript expression was confirmed in brain, skeletal muscle, and pancreatic islet extracts. (J:146345)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gper1 Mutation: 30 strains or lines available

References

• Original: J:146345 Martensson UE, et al., Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 2009 Feb;150(2):687-98
• All: 6 reference(s)