Pax6^m1Lsli
Chemically induced Allele Detail

Summary

• Symbol: Pax6^m1Lsli
• Name: paired box 6; mutant 1, Lingsong Li
• MGI ID: MGI:3837670
• Synonyms: Pax6^m
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^m1Lsli page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU treatment generated an A to T transversion that led to the amino acid substitution of a STOP codon for arginine at position 266 (R266X). This allele produces a truncated protein at amino acid 266. (J:146325)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:146325 Wen JH, et al., Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia. 2009 Mar;52(3):504-13
• All: 4 reference(s)