Rev3l^tm1.1Rsky
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm1.1Rsky
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1.1, Klaus Rajewsky
• MGI ID: MGI:3837725
• Synonyms: Pol-zeta^delta
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm1.1Rsky page

Chromosome aberrations in B cells of Rev3l^tm1Rsky/Rev3l^tm1.1Rsky Tg(Cr2-cre)3Cgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146453
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: Mice carrying the Rev3l^tm1Rsky allele were crossed with cre deleter mice to remove the floxed exon. Exon excision was confirmed by gene amplification and subsequent sequencing of the PCR product. This is considered a null allele. (J:146453)

Generation of the Rev3l^tm1Rsky and Rev3l^tm1.1Rsky alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 120 strains or lines available

References

• Original: J:146453 Schenten D, et al., Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med. 2009 Feb 16;206(2):477-90
• All: 1 reference(s)