Camk2d^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Camk2d^tm1.2Eno
• Name: calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:3837728
• Synonyms: CaMKIIdelta^-
• Gene: Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
• Alliance: Camk2d^tm1.2Eno page

Diminished cardiac hypertrophy of Camk2d^tm1.2Eno/Camk2d^tm1.2Eno mice after thoracic aortic constriction

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146285
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination was used to remove exons 1 and 2. The absence of protein expression was confirmed by western blot analysis on cardiac extracts. (J:146285)

Generation of the Camk2d^tm1.1Eno and Camk2d^tm1.2Eno alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2d Mutation: 44 strains or lines available

References

• Original: J:146285 Backs J, et al., The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7
• All: 12 reference(s)