Tslp^tm1.1Pcn
Targeted Allele Detail

Summary

• Symbol: Tslp^tm1.1Pcn
• Name: thymic stromal lymphopoietin; targeted mutation 1.1, Pierre Chambon
• MGI ID: MGI:3837749
• Synonyms: Tslp^L2
• Gene: Tslp Location: Chr18:32948436-32952850 bp, + strand Genetic Position: Chr18, 18.12 cM
• Alliance: Tslp^tm1.1Pcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146511
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:146511)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tslp Mutation: 15 strains or lines available

References

• Original: J:146511 Li M, et al., Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol. 2009 Feb;129(2):498-502
• All: 4 reference(s)