Col1a1^{tm1(CAG-EGFR)Char}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(CAG-EGFR)Char}
• Name: collagen, type I, alpha 1; targeted mutation 1, Al Charest
• MGI ID: MGI:3837824
• Synonyms: Col1alpha1-EGFR^WT
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(CAG-EGFR)Char} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146494
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Col1a1^{tm1(CAG-EGFR)Char} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: A CAG promoter was used to drive expression of a wild-type human EGFR with an intervening floxed STOP cassette inserted into the 3' untranslated region. (J:146494)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

References

• Original: J:146494 Zhu H, et al., Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6
• All: 4 reference(s)