Mstn^lean
Chemically induced Allele Detail

Summary

• Symbol: Mstn^lean
• Name: myostatin; lean
• MGI ID: MGI:3838011
• Synonyms: Mstn^Ln
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^lean page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Following multidose N-ethyl-N-nitrosourea (ENU) treatments to induce mutations in founder C57BL/6J mice, a T->C transition was found in the second intron two base pairs downstream of exon 2 (a splice donor position conserved in almost all vertebrate introns) in the myostatin (Mstn) gene. (J:146513)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:146513 Wilkes JJ, et al., Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance. Diabetes. 2009 May;58(5):1133-43
• All: 4 reference(s)