Pard3^tm1.1Shoh
Targeted Allele Detail

Summary

• Symbol: Pard3^tm1.1Shoh
• Name: par-3 family cell polarity regulator; targeted mutation 1.1, Shigeo Ohno
• MGI ID: MGI:3838017
• Synonyms: Par3^deltaE3
• Gene: Pard3 Location: Chr8:127790643-128338767 bp, + strand Genetic Position: Chr8, 74.66 cM, cytoband E2
• Alliance: Pard3^tm1.1Shoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146415
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette and exon 3. Deletion of this exon results in a frame-shift mutation and premature termination in the CR1 domain. The absence of protein expression was confirmed by western blot analysis on E11.5 embryo extracts. (J:146415)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pard3 Mutation: 96 strains or lines available

References

• Original: J:146415 Hirose T, et al., PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
• All: 2 reference(s)