Caly^tm1.1Cber
Targeted Allele Detail

Summary

• Symbol: Caly^tm1.1Cber
• Name: calcyon neuron-specific vesicular protein; targeted mutation 1.1, Clare Bergson
• MGI ID: MGI:3838019
• Synonyms: Cal^-
• Gene: Caly Location: Chr7:139649793-139662461 bp, - strand Genetic Position: Chr7, 85.07 cM
• Alliance: Caly^tm1.1Cber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146583
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice homozygous for the floxed Caly^tm1Cber allele were crossed with Tg(CMV-cre)1Cgn transgenic mice to generate null homozygotes that were then used for further breeding. No mRNA was detectable by RT-PCR on cortex and hind-brain extracts from homozygotes. (J:146583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Caly Mutation: 12 strains or lines available

References

• Original: J:146583 Xiao J, et al., Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J Biol Chem. 2006 Jun 2;281(22):15182-93
• All: 2 reference(s)