Numa1^tm1.1Dwc
Targeted Allele Detail

Summary

• Symbol: Numa1^tm1.1Dwc
• Name: nuclear mitotic apparatus protein 1; targeted mutation 1.1, Don W Cleveland
• MGI ID: MGI:3838102
• Synonyms: NuMA^flox
• Gene: Numa1 Location: Chr7:101583318-101664171 bp, + strand Genetic Position: Chr7, 54.7 cM
• Alliance: Numa1^tm1.1Dwc page

Spindle defects in primay Numa1^tm1.1Dwc/Numa1^tm1.1Dwc Tg(CAG-cre/Esr1*)5Amc/0 fibroblasts

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146214
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 22 floxed. (J:146214)

Generation of the Numa1^tm1Dwc, Numa1^tm1.1Dwc, and Numa1^tm1.2Dwc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Numa1 Mutation: 78 strains or lines available

References

• Original: J:146214 Silk AD, et al., Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol. 2009 Mar 9;184(5):677-90
• All: 5 reference(s)