Ltn1^lister
Chemically induced Allele Detail

Summary

• Symbol: Ltn1^lister
• Name: listerin E3 ubiquitin protein ligase 1; lister
• MGI ID: MGI:3838105
• Gene: Ltn1 Location: Chr16:87173539-87229500 bp, - strand Genetic Position: Chr16, 49.52 cM
• Alliance: Ltn1^lister page

Progressive impairment of neuronal and motor functions associated with weight loss and reduced life span in Ltn1^lister/Ltn1^lister mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to T transversion is present at a splice donor site. The resulting transcript lacks exon 11 producing a mutant protein that lacks the 14 amino acids (708 -721) encoded by this exon. Both the mutant transcript and protein are expressed. (J:146493)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ltn1 Mutation: 95 strains or lines available

References

• Original: J:146493 Chu J, et al., A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103
• All: 1 reference(s)