Ltn1^{Gt(RRR322)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ltn1^{Gt(RRR322)Byg}
• Name: listerin E3 ubiquitin protein ligase 1; gene trap RRR322, BayGenomics
• MGI ID: MGI:3838106
• Synonyms: RRR322
• Gene: Ltn1 Location: Chr16:87173539-87229500 bp, - strand Genetic Position: Chr16, 49.52 cM
• Alliance: Ltn1^{Gt(RRR322)Byg} page

Mutation origin

• Mutant Cell Line: RRR322
• Germline Transmission: Earliest citation of germline transmission: J:146493
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• The gene trap vector was inserted into intron 25 by random integration. (J:146493)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRR322	CG784823 ; (MGI Seq Detail)	5' RACE	Chr16:87191412-87195584 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltn1 Mutation: 95 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:146493 Chu J, et al., A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103
• All: 2 reference(s)