Cacng1^tm1Rgg
Targeted Allele Detail

Summary

• Symbol: Cacng1^tm1Rgg
• Name: calcium channel, voltage-dependent, gamma subunit 1; targeted mutation 1, Ronald G Gregg
• MGI ID: MGI:3838110
• Gene: Cacng1 Location: Chr11:107594044-107607302 bp, - strand Genetic Position: Chr11, 70.29 cM, cytoband E1
• Alliance: Cacng1^tm1Rgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146419
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of detectable protein expression in muscles from homozygous mice. (J:146419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacng1 Mutation: 14 strains or lines available

References

• Original: J:146419 Ahern CA, et al., Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle. BMC Physiol. 2001;1:8
• All: 1 reference(s)