Del(11Nme2-Nme1)1Zou
Targeted Allele Detail

Summary

• Symbol: Del(11Nme2-Nme1)1Zou
• Name: deletion, Chr 11, Xiaoming Zou 1
• MGI ID: MGI:3838141
• Synonyms: Nme1/Nme2^tm1Zou
• Gene: Del(11Nme2-Nme1)1Zou Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Nme2-Nme1)1Zou involves 3 genes/genome features (Nme2, Nme1nme2, Nme1) View all
• Mutation details: An about 15 kb fragment including the coding regions of both Nme1 and Nme2 was replaced with a floxed neo cassette via homologous recombination. MEFs from homozygous mice have no detectable protein or enzyme activity. (J:146219)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Nme2-Nme1)1Zou Mutation: 0 strains or lines available

References

• Original: J:146219 Postel EH, et al., Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn. 2009 Mar;238(3):775-87
• All: 3 reference(s)