Tg(Myh6-MYL2*D166V)1Dsc
Transgene Detail
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Symbol: |
Tg(Myh6-MYL2*D166V)1Dsc |
Name: |
transgene insertion 1, Danuta Szczesna-Cordary |
MGI ID: |
MGI:3838172 |
Synonyms: |
Tg-D166V |
Transgene: |
Tg(Myh6-MYL2*D166V)1Dsc Location: unknown
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Alliance: |
Tg(Myh6-MYL2*D166V)1Dsc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-MYL2*D166V)1Dsc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYL2 (4633) |
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Mutation details: The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third was used to drive cardiac-specific expression of a mutated human cDNA derived from patient with familial hypertrophic cardiomyopathy that contains an amino acid substitution of valine for aspartic acid at position 166 (D166V). No line information was given.
(J:146091)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:146091 Kerrick WG, et al., Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice. FASEB J. 2009 Mar;23(3):855-65 |
All: |
9 reference(s) |
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