Cr1l^tm1.1Song
Targeted Allele Detail

Summary

• Symbol: Cr1l^tm1.1Song
• Name: complement C3b/C4b receptor 1 like; targeted mutation 1.1, Wen-Chao Song
• MGI ID: MGI:3838179
• Synonyms: Crry^flox
• Gene: Cr1l Location: Chr1:194781019-194813878 bp, - strand Genetic Position: Chr1, 98.43 cM
• Alliance: Cr1l^tm1.1Song page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146538
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5, and an frt flanked neo cassette with a 3' loxP site was inserted downstream of eoxn 5. Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:146538)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr1l Mutation: 30 strains or lines available

References

• Original: J:146538 Miwa T, et al., Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood. 2009 Mar 19;113(12):2684-94
• All: 3 reference(s)