Agpat2^tm1Garg
Targeted Allele Detail

Summary

• Symbol: Agpat2^tm1Garg
• Name: 1-acylglycerol-3-phosphate O-acyltransferase 2; targeted mutation 1, Abhimanyu Garg
• MGI ID: MGI:3838346
• Gene: Agpat2 Location: Chr2:26483069-26494429 bp, - strand Genetic Position: Chr2, 18.96 cM
• Alliance: Agpat2^tm1Garg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146649
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence spanning from upstream of exon 1 through exon 4 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. Enzymatic activity of the targeted protein is reduced to 10% of wild-type. (J:146649)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agpat2 Mutation: 21 strains or lines available

References

• Original: J:146649 Cortes VA, et al., Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 2009 Feb;9(2):165-76
• All: 10 reference(s)