Id2^tm1Mais
Targeted Allele Detail

Summary

• Symbol: Id2^tm1Mais
• Name: inhibitor of DNA binding 2; targeted mutation 1, Mark A Israel
• MGI ID: MGI:3838359
• Synonyms: Id2^tm1Jdu
• Gene: Id2 Location: Chr12:25143798-25146091 bp, - strand Genetic Position: Chr12, 8.57 cM, cytoband B
• Alliance: Id2^tm1Mais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146624
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector containing the neomycin resistance cassette was used to replace a region 560 bp 5' upstream of the transcription start site and exons 1 and 2 using homologous recombination. Exons 1-2 encode the entire coding domain. Western blot and immunoprecipitation of xx tissues confirmed that no protein was expressed in mutant mice. Western blot analysis of liver tissues confirmed that no protein was expressed in mutant mice. (J:146624)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Id2 Mutation: 21 strains or lines available

References

• Original: J:146624 Duffield GE, et al., A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol. 2009 Feb 24;19(4):297-304
• All: 6 reference(s)