Hand2^tm2Eno
Targeted Allele Detail

Summary

• Symbol: Hand2^tm2Eno
• Name: heart and neural crest derivatives expressed 2; targeted mutation 2, Eric N Olson
• MGI ID: MGI:3838372
• Synonyms: Hand2^EDE
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146638
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of glutamic acid, aspartic acid, and glutamic acid for the three arginines at positions 109 to 111. These arginines are necessary for DNA binding activity. An frt flanked neo cassette inserted downstream of exon 1 was removed by germ line, flp mediated recombination. (J:146638)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:146638 Liu N, et al., DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development. 2009 Mar;136(6):933-42
• All: 1 reference(s)