Usp1^tm1.1Ada
Targeted Allele Detail

Summary

• Symbol: Usp1^tm1.1Ada
• Name: ubiquitin specific peptidase 1; targeted mutation 1.1, Alan D D'Andrea
• MGI ID: MGI:3838373
• Synonyms: Usp1^-
• Gene: Usp1 Location: Chr4:98812047-98823780 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Usp1^tm1.1Ada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146616
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites with a FRT-flanked neomycin resistance cassette placed downstream. Before microinjection into blastocystes, the neomycin cassette was excised by transient expression of Flp-recombinase. Mice were crossed with EIIa-cre transgenic mice to remove the floxed allele. No protein was detected by immunoblot analysis of homozygote embryonic fibroblast lysates. (J:146616)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp1 Mutation: 47 strains or lines available

References

• Original: J:146616 Kim JM, et al., Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell. 2009 Feb;16(2):314-20
• All: 3 reference(s)