Heg1^tm1Mlkn
Targeted Allele Detail

Summary

• Symbol: Heg1^tm1Mlkn
• Name: heart development protein with EGF-like domains 1; targeted mutation 1, Mark L Kahn
• MGI ID: MGI:3838392
• Gene: Heg1 Location: Chr16:33504754-33591946 bp, + strand Genetic Position: Chr16, 24.17 cM
• Alliance: Heg1^tm1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a LacZ gene and neo cassette via homologous recombination. RT-PCR confirmed the absence of RNA expression in homozygous embryos. (J:146528)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Heg1 Mutation: 56 strains or lines available

References

• Original: J:146528 Kleaveland B, et al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
• All: 2 reference(s)