Acss1^tm1Jsak
Targeted Allele Detail

Summary

• Symbol: Acss1^tm1Jsak
• Name: acyl-CoA synthetase short-chain family member 1; targeted mutation 1, Juro Sakai
• MGI ID: MGI:3838396
• Synonyms: AceCS2^-
• Gene: Acss1 Location: Chr2:150460031-150510160 bp, - strand Genetic Position: Chr2, 74.74 cM
• Alliance: Acss1^tm1Jsak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ reporter and a floxed neomycin selection cassette. Absence of transcripts was established by QRT-PCR and absence of protein product was confirmed by immunoblot analysis. (J:146647)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acss1 Mutation: 33 strains or lines available

References

• Original: J:146647 Sakakibara I, et al., Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009 Feb;9(2):191-202
• All: 1 reference(s)