Fcgrt^tm1Esw
Targeted Allele Detail

Summary

• Symbol: Fcgrt^tm1Esw
• Name: Fc fragment of IgG receptor and transporter; targeted mutation 1, E Sally Ward
• MGI ID: MGI:3838491
• Synonyms: FcRn^f
• Gene: Fcgrt Location: Chr7:44742417-44753246 bp, - strand Genetic Position: Chr7, 29.12 cM
• Alliance: Fcgrt^tm1Esw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin cassette was placed upstream of exon 5 in a Hind-III restriction site, and a loxP site was placed downstream of exon 7 in a Bam-HI site. Correct targeting was confirmed by Southern blotting. Gene expression was unaffected as demonstrated by in situ staining of small intestine epithelial cells. (J:146640)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcgrt Mutation: 61 strains or lines available

References

• Original: J:146640 Montoyo HP, et al., Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2788-93
• All: 7 reference(s)