Tg(Cyp39a1-cre)1Aibs
Transgene Detail

Summary

• Symbol: Tg(Cyp39a1-cre)1Aibs
• Name: transgene insertion 1, Ed Lein
• MGI ID: MGI:3838493
• Synonyms: Cyp39a1-Tg1-Cre
• Transgene: Tg(Cyp39a1-cre)1Aibs Location: unknown
• Alliance: Tg(Cyp39a1-cre)1Aibs page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cyp39a1-cre)1Aibs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cyp39a1 (MGI:1927096)

• Mutation details: The 206 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-370M9, containing the entire Cyp39a1 locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Cyp39a1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre expression is directed to cortex, hippocampus and cerebellum by the Cyp39a1 promoter/enhancer regions within the BAC transgene. (J:146821)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp39a1 (mouse) Summary of all recombinase alleles driven by Cyp39a1. Comparative matrix view of recombinase activities Alliance mouse Cyp39a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:146821 Allen Institute for Brain Science, Cre transgenes and knockin alleles created at the Allen Insitute for Brain Science (AIBS). MGI Direct Data Submission. 2009-04-06
• All: 5 reference(s)