Tg(Scnn1a-cre)2Aibs
Transgene Detail

Summary

• Symbol: Tg(Scnn1a-cre)2Aibs
• Name: transgene insertion 2, Ed Lein
• MGI ID: MGI:3838498
• Synonyms: Scnna1-Tg2-Cre
• Transgene: Tg(Scnn1a-cre)2Aibs Location: unknown
• Alliance: Tg(Scnn1a-cre)2Aibs page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Scnn1a-cre)2Aibs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scnn1a (MGI:101782)

• Mutation details: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405B24, containing the entire Scnn1a locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Scnn1a locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre expression is directed to cortex, thalamus, midbrain and cerebellum by the Scnn1a promoter/enhancer regions within the BAC transgene. (J:146821, J:155793)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scnn1a (mouse) Summary of all recombinase alleles driven by Scnn1a. Alliance mouse Scnn1a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40
• All: 12 reference(s)