Gsdma3^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gsdma3^M1Btlr
• Name: gasdermin A3; mutation 1, Bruce Beutler
• MGI ID: MGI:3838513
• Synonyms: Michelin
• Gene: Gsdma3 Location: Chr11:98517186-98529052 bp, + strand Genetic Position: Chr11, 62.21 cM
• Alliance: Gsdma3^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered by its visible phenotype among G1 progeny of an ENU mutagenized mouse. It comprises an A to T transversion at nucleotide position 1178, in the tenth of the gene's 11 exons, that replaces a triplet encoding lysine with a premature transcription termination codon at amino acid position 366 (K366Ter) and truncates the protein by 98 amino acids at its carboxyl terminus. (J:146738)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsdma3 Mutation: 26 strains or lines available

References

• Original: J:146738 Sun L, et al., Record for "Fuzzy", updated March 30, 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)