Pdgfra^tm13.1Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfra^tm13.1Sor
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 13.1, Philippe Soriano
• MGI ID: MGI:3838516
• Synonyms: PDGFRalpha^J
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^tm13.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146617
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: Germ line, cre mediated recombination was used to remove the floxed neo-STOP cassette allowing for expression of the cDNA with the V561D mutation. (J:146617)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:146617 Olson LE, et al., Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell. 2009 Feb;16(2):303-13
• All: 1 reference(s)