Drinkmgcl25^PWK/PhJ
QTL Variant Detail

Summary

• QTL variant: Drinkmgcl25^PWK/PhJ
• Name: drink magnesium chloride 2 5; PWK/PhJ
• MGI ID: MGI:3838595
• QTL: Drinkmgcl25 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: PWK/PhJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased magnesium chloride preference and intake compared to C57BL/6J. (J:144262)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144262

Linkage analysis was performed on (C57BL/6J x PWK/PhJ)F2 animals to identify genetic loci associated with preference and intake of calcium and other salt compounds. Animals were subjected to a two-bottle choice test between water and one other solution (CaCl2, CaLa, MgCl2, KCl, NH4Cl, NaCl, citric acid, QHCl, or saccharin) for a period of 96 hours. PWK/PhJ is a high consumer of calcium chloride (CaCl2) and calcium lactate (CaLa) whereas C57BL/6J is a relatively low consumer. PWK/PhJ also consumes more MgCl2 compared to C57BL/6J. However, when consumption of KCl, NaCl and saccharin were analyzed, C57BL/6J animals consumed more of these solutions compared to PWK/PhJ animals. Linkage analysis was performed using 116 polymorphic markers at a resolution of 10cM - 30cM. Thirty QTLs reaching statistical significance were identified. Authors assigned separate QTL nomenclature for each of the salt compound QTL even if they mapped to the same linkage marker.

On mouse Chromosome 10, significant linkage was detected for magnesium chloride intake (LOD=7.1) and preference (LOD=5.7) at 24 Mb near D10Mit86 and calcium chloride intake (LOD=3.8) and preference (LOD=4.3) at 92 Mb near D10Mit95. These loci are named Drinkmgcl25 (drink magnesium chloride 2 5) and Drinkcacl23 (drink calcium chloride 2 3), respectively. Drinkmgcl25 explains 6.7% of the MgCl2 intake and 5.4% of the preference while Drinkcacl23 explains 3.7% of the CaCl2 intake and 4.2% of the preference. PWK/PhJ-derived alleles at Drinkmgcl25 and Drinkcacl23 confer increased magnesium chloride and calcium chloride consumption and preference, respectively.

References

• Original: J:144262 Tordoff MG, et al., Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice. Genes Brain Behav. 2008 Aug;7(6):618-28
• All: 1 reference(s)