Tg(tetO-DISC1*)1001Plet
Transgene Detail

Summary

• Symbol: Tg(tetO-DISC1*)1001Plet
• Name: transgene insertion 1001, Mikhail Pletnikov
• MGI ID: MGI:3838645
• Synonyms: Tg(tetO/CMV-DISC1*)1001Plet, Tg(TRE-CMVhDISC1)
• Transgene: Tg(tetO-DISC1*)1001Plet Location: unknown
• Alliance: Tg(tetO-DISC1*)1001Plet page

Transgene origin

• Strain of Origin: C57BL/6 and SJL

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-DISC1*)1001Plet expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DISC1 (27185)

  Disc1

  (MGI:2447658)

• Mutation details: The transgene construct was designed with the myc peptide tagged mutant human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Founder line 1001, which showed strong expression, was established. A second line, line 70, shows a weak expression of human DISC1. (J:146881)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:146881 Pletnikov MV, et al., Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry. 2008 Feb;13(2):173-86, 115
• All: 14 reference(s)