Dek^tm1Siwe
Targeted Allele Detail

Summary

• Symbol: Dek^tm1Siwe
• Name: DEK proto-oncogene; targeted mutation 1, Susanne I Wells
• MGI ID: MGI:3838711
• Gene: Dek Location: Chr13:47238251-47259677 bp, - strand Genetic Position: Chr13, 24.5 cM, cytoband B1
• Alliance: Dek^tm1Siwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146608
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing IRES-lacZ-neo was inserted into exon 6. The absence of protein expression was confirmed by western blot analysis on primary keratinocytes and bone marrow. (J:146608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dek Mutation: 32 strains or lines available

References

• Original: J:146608 Wise-Draper TM, et al., Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. Cancer Res. 2009 Mar 1;69(5):1792-9
• All: 11 reference(s)