Cacna1f^tm1.1Sdie
Targeted Allele Detail

Summary

• Symbol: Cacna1f^tm1.1Sdie
• Name: calcium channel, voltage-dependent, alpha 1F subunit; targeted mutation 1.1, Susanne tom Dieck
• MGI ID: MGI:3838717
• Synonyms: Cacna1f^deltaEx14-17
• Gene: Cacna1f Location: ChrX:7473342-7501435 bp, + strand Genetic Position: ChrX, 3.42 cM
• Alliance: Cacna1f^tm1.1Sdie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146683
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exons 14 through 17. Expression of a truncated protein was confirmed by western blot analysis on retinal extracts. (J:146683)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1f Mutation: 19 strains or lines available

References

• Original: J:146683 Specht D, et al., Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):505-15
• All: 15 reference(s)