Tg(Gfap-cre)77.6Mvs
Transgene Detail

Summary

• Symbol: Tg(Gfap-cre)77.6Mvs
• Name: transgene insertion 77.6, Michael V Sofroniew
• MGI ID: MGI:3838840
• Synonyms: mGFAP-Cre
• Transgene: Tg(Gfap-cre)77.6Mvs Location: unknown
• Alliance: Tg(Gfap-cre)77.6Mvs page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6NHsd)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gfap-cre)77.6Mvs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• Mutation details: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus. (J:94543, J:146630)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Comparative matrix view of recombinase activities Alliance mouse Gfap gene page

Disease models

Expression

In Mice Carrying this Mutation:

13 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:146630 Gregorian C, et al., Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):1874-86
• All: 118 reference(s)