Grb10^tm1.1Fuis
Targeted Allele Detail

Summary

• Symbol: Grb10^tm1.1Fuis
• Name: growth factor receptor bound protein 10; targeted mutation 1.1, Fumitoshi Ishino
• MGI ID: MGI:3839230
• Synonyms: Meg1deltaDMR
• Gene: Grb10 Location: Chr11:11880499-11987428 bp, - strand Genetic Position: Chr11, 7.15 cM
• Alliance: Grb10^tm1.1Fuis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146865
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1b was replaced with a floxed neo cassette that was subsequently removed by germ line, cre mediated recombination. At E12.5, mice exhibit 1.93-fold greater than wild-type biallelic expression of the type I transcript that lacks the differentially methylated region (DMR). (J:146865)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grb10 Mutation: 56 strains or lines available

References

• Original: J:146865 Shiura H, et al., Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Hum Mol Genet. 2009 Apr 15;18(8):1424-38
• All: 2 reference(s)