Atf6^tm1Kamo
Targeted Allele Detail

Summary

• Symbol: Atf6^tm1Kamo
• Name: activating transcription factor 6; targeted mutation 1, Kazutoshi Mori
• MGI ID: MGI:3839240
• Synonyms: ATFalpha^-
• Gene: Atf6 Location: Chr1:170532243-170695340 bp, - strand Genetic Position: Chr1, 76.96 cM
• Alliance: Atf6^tm1Kamo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145116
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced with a floxed promoter trap containing an splice acceptor, IRES, beta-geo cassette, and polyadenylation signal. These exons code for the entire basic leucine zipper and most of the transmembrane domain. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast lysates. (J:145116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf6 Mutation: 45 strains or lines available

References

• Original: J:145116 Yamamoto K, et al., Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell. 2007 Sep;13(3):365-76
• All: 23 reference(s)