Atf6b^tm1Kamo
Targeted Allele Detail

Summary

• Symbol: Atf6b^tm1Kamo
• Name: activating transcription factor 6 beta; targeted mutation 1, Kazutoshi Mori
• MGI ID: MGI:3839241
• Synonyms: ATF6beta^-
• Gene: Atf6b Location: Chr17:34866120-34874048 bp, + strand Genetic Position: Chr17, 18.22 cM
• Alliance: Atf6b^tm1Kamo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145116
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 and 11 were replaced with a floxed promoter trap containing an splice acceptor, IRES, beta-geo cassette, and polyadenylation signal. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast lysates. (J:145116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf6b Mutation: 43 strains or lines available

References

• Original: J:145116 Yamamoto K, et al., Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell. 2007 Sep;13(3):365-76
• All: 5 reference(s)