Mterf3^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Mterf3^tm1.1Lrsn
• Name: mitochondrial transcription termination factor 3; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:3839255
• Synonyms: MTERF3^loxP
• Gene: Mterf3 Location: Chr13:67055032-67081152 bp, - strand Genetic Position: Chr13, 34.54 cM, cytoband B3
• Alliance: Mterf3^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145125
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, which contains the translation initiation site, and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette. (J:145125)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mterf3 Mutation: 27 strains or lines available

References

• Original: J:145125 Park CB, et al., MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell. 2007 Jul 27;130(2):273-85
• All: 3 reference(s)