Smad3^tm1Sche
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1Sche
• Name: SMAD family member 3; targeted mutation 1, Sheldon Chen
• MGI ID: MGI:3839291
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1Sche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145114
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:145114)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 22 strains or lines available

References

• Original: J:145114 Wang A, et al., Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1657-65
• All: 1 reference(s)