Htr6^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Htr6^tm1Arte
• Name: 5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:3839298
• Gene: Htr6 Location: Chr4:138788419-138802881 bp, - strand Genetic Position: Chr4, 70.57 cM
• Alliance: Htr6^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145073
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with one in which nucleotide substitutions resulted in the amino acid substitutions of leucine for phenylalanine at position 69 (F69L), isoleucine for threonine at position 71 (T71I), and alanine for aspartic acid at position 72 (D72A). An frt flanked neo cassette was inserted downstream of exon 1. (J:145073)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr6 Mutation: 27 strains or lines available

References

• Original: J:145073 Frassetto A, et al., Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain Res. 2008 Oct 21;1236:140-4
• All: 1 reference(s)