Sohlh2^tm1Rajk
Targeted Allele Detail

Summary

• Symbol: Sohlh2^tm1Rajk
• Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2; targeted mutation 1, Aleksandar Rajkovic
• MGI ID: MGI:3839324
• Gene: Sohlh2 Location: Chr3:55089465-55117378 bp, + strand Genetic Position: Chr3, 26.53 cM
• Alliance: Sohlh2^tm1Rajk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145802
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR. (J:145802)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sohlh2 Mutation: 27 strains or lines available

References

• Original: J:145802 Choi Y, et al., Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression. Biol Reprod. 2008 Dec;79(6):1176-82
• All: 4 reference(s)